منابع مشابه
Human neutrophil elastase inhibitors in innate and adaptive immunity.
Recent evidence shows that human neutrophil elastase inhibitors can be synthesized locally at mucosal sites. In addition to efficiently targeting bacterial and host enzymes, they can be released in the interstitium and in the lumen of mucosa, where they have been shown to have antimicrobial activities, and to activate innate immune responses. This review will address more particularly the pleio...
متن کاملNeutrophil elastase in bronchiectasis
The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systema...
متن کاملEffects of Neutrophil Elastase
A bstract. The effects of neutrophil elastase on endothelial prostacyclin (PGI2) production, nucleotide release, and responsiveness to vasoactive agents were compared with the effects of cathepsin G (the other major neutral protease of neutrophils), pancreatic elastase, trypsin, chymotrypsin, and thrombin. PGI2 production by pig aortic endothelial cells cultured on microcarrier beads and perfus...
متن کاملCrystallization of human neutrophil elastase.
Human neutrophil elastase was inactivated by methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Ala-chloromethane. The modified enzyme was crystallized from 40 mM ammonium phosphate, pH 7.0 in the hexagonal space group P6(3) with unit cell parameters a = 74.53 A, b = 74.53 A, c = 70.88 A, alpha = beta = 90 degrees, gamma = 120 degrees. These crystals were resistant to radiation damage and diffracted beyond 1....
متن کاملNeutrophil elastase and trastuzumab responsiveness.
Accessible online at: www.karger.com/onk Fax +49 761 4 52 07 14 E-mail [email protected] www.karger.com 4D5. HER2 gene encodes a 185-kDa transmembrane glycoprotein receptor (p185HER2), which is amplified in 25–30% of human breast cancers. When amplified, the gene produces high levels of HER2 surface receptor expression. Patients with breast cancer whose tumors demonstrate HER2 gene amplific...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Expert Opinion on Therapeutic Patents
سال: 2011
ISSN: 1354-3776,1744-7674
DOI: 10.1517/13543776.2011.551115